These treatments have truly revolutionized the treatment of macular degeneration, diabetic macular edema and retinal vein occlusions, and are usually very effective at minimizing vision loss. These treatments are performed in the office: the eye is numbed up using anesthetic eye drops. Usually a local anesthetic is applied to the outer white part of the eye (conjunctiva), after which a small needle is used to inject the medicine (anti-VEGF agent, such as Avastin, Eylea or Lucentis; or steroid) into the vitreous gel in the middle of the eye. Most of the time, this procedure is virtually painless.